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| 1 | Stress kinase inhibition modulates acute experimental pancreatitis显示文摘AIM To examine the role of p38 during acute experimental cerulein pancreatitis.METHODS Rats were treated with cerulein with or without a specific JNK inhibitor (CEP1347)andy or a specific p38 inhbitor (SB203380) and pancreatic stress kinase activity wasdetermined. Parameters to assess pancreatitis included trypsin, amylase, lipase, pancreatic weight and histology.RESULTS JNK inhibition with CEP1347ameliorated pancreatitis, reducing pancreatic edema. In contrast, p38 inhibition with SB203580aggravated pancreatitis with higher trypsinlevels and, with induction of acinar necrosis not normally found after cerulein hyperstimulation.Simultaneous treatment with both CEP1347 and SB203580 mutually abolished the effects of either compound on cerulein pancreatitis.CONCLUSION Stress kinases modulatepancreatitis differentially. JNK seems to promote pancreatitis development, possibly by supporting inflammatory reactions such as edema formation while its inhibition ameliorates pancreatitis. In contrast, p38 may help reduce organ destruction while inhibition of p38 during induction of cerulein pancreatitis leads to the occurrence of acinar necrosis. | F.Fleischer R.Dabew B.Goke ACC Wagner | 2001 | World Journal of Gastroenterology2001，7，2： | 16 |
| 2 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 3 | 慢性稳定型心绞痛诊疗指南(续)(1999年)显示文摘 | ——美国心脏病学院(ACC)/美国心脏学会(AHA)/
美国医师学院及美国内科学会(ACP-ASIM)联合议定 | 2000 | 岭南心血管病杂志2000，6，4： | 3 |
| 4 | 心室晚电位(应用高分辨或信息平均心电图分析标准显示文摘过去十年中,许多研究者在实验动物与易患持久性室性心动过速的病人记录到位于QRS波终末的低振幅、高频波,以及频谱改变成份。这些微伏水平的波被称为晚电位(LP)。用不同信息处理方法、不同的晚电位定义以及不同病人对象的文献报道结果,晚电位的患病率为60%~90%。相反,应用基本相同的记录技术的文献,所报导的正常人群晚电位发生率低,在0%—7%。记录上述异常信息的技术称为高分辨心电图。现有仪器的技术条件颇不相同,为使应用这些不同仪器所得结果能相互比较,迫切需要记录单元和分析算法的标准化。高分辨心电图对病人监护的影响,最终决定于其识别室性心动过速易患病人的能力。 | ESC/AHA/ACC特别工作组 浦寿月 | 1992 | 临床心电学杂志1992，1，1： | 2 |
| 5 | Guideline for clinical use of cardiac radiomuclide imaging显示文摘 | ACC/AHA | 1995 | J Am Coll Cardiol1995，25，： | 1 |
| 6 | A report of the American college of/American heart association task force on practice guidelines显示文摘 | ACC/HAH guidelines for the management of patiens with unstable angina and non- ST - segment elevation myocardial infarction | 2000 | JACC2000，36，： | 1 |
| 7 | 2005 Guideline update for the diagnosis and management of chronic heart failure in the adult显示文摘 | ACC/AHA | 2005 | Circulation2005，112，4： | 1 |
| 8 | VIBEX: an expert system for vibration fault diagnosis of rotating machinery using decision tree and decision table显示文摘 | YangBS LimDS Tan ACC | 2005 | Expert Systems with Applications2005，，28： | 1 |
| 9 | A Report of American College of Cardiology/American Heart Association Task Force or Practice Guidelines显示文摘 | ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation mycardical infarction | 2000 | GACC2000，36，2： | 1 |
| 10 | Fibronectin regulates activation of THP-1 cells by TGF-β1 显示文摘 | wang ACC Fu C | 2001 | Inflammation Research2001，50，： | 1 |
| 11 | A report American collage of cardiology/American heart association task force or practice guidelines显示文摘 | ACC/AHA·Guidelines for the management of patientswith unstable angina and non-st-segment elevation myocardial infarction | 2000 | J Am Coll Cardiol2000，，36： | 1 |
| 12 | Guidelines for the Management of Patients With Atrial Fibrillation显示文摘 | ACC/AHA/ESC | 2006 | JACC2006，48，11： | 1 |
| 13 | Task force report,guidelines for the evaluation and management of heart failure显示文摘 | ACC/AHA | 2001 | Circulation2001，38，7： | 1 |
| 14 | A re- port of the American College of Cardiology Foundation/American Heart Associ - ation Task Force on Practice Guidelines 显示文摘 | 2009 focused update incorporated into the ACC/AHA 2005 Guideline for the Diagnosis and Management of Heart Failure in Adults | 2009 | Circula- tion2009，119，14： | 1 |
| 15 | RAP1 GTPase overexpress:on is associated with cervical intraepithelial neoplasia显示文摘 | Pascoal-Xavier MA Figueiredo ACC Gomes LI | 2015 | PLoS One2015，10，01： | 1 |
| 16 | a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | 2009 focused update incorporated into the ACC/AHA 2005 Guideline for the Diagnosis and Management of Heart Failure in Adults | 2009 | Circulation2009，119，14： | 1 |
| 17 | A report of American college of cardiology/American heart association task force or practice guidelines显示文摘 | ACC/AHA Guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction | 2000 | J Am Coll Cardiol2000，36，： | 1 |
| 18 | Guidelines for the evaluation and management ofchronic heart failure显示文摘 | ACC/AHA | 2001 | Circulation2001，104，： | 1 |
| 19 | Comparative study of agar diffusion test and the NCCLS macrobroth method for in vitro susceptibility testing of Candida spp显示文摘 | Soni LMF Burattini MN Pignatari ACC | 1999 | Mycopathologia1999，145，3： | 1 |
| 20 | Mutation in the KCNQ1 gene leading to the short QT-interval syndrome显示文摘 | Bellocq C van Ginneken ACC Bezzina CR | 2004 | Circulation2004，109，： | 1 |
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