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| 1 | Metabolic aspects of adult patients with nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is a major cause of chronic liver disease and it encompasses a spectrum from simple steatosis to steatohepatitis, fibrosis, or cirrhosis. The mechanisms involved in the occurrence of NAFLD and its progression are probably due to a metabolic profile expressed within the context of a genetic predisposition and is associated with a higher energy intake. The metabolic syndrome(MS) is a cluster of metabolic alterations associated with an increased risk for the development of cardiovascular diseases and diabetes. NAFLD patients have more than one feature of the MS, and now they are considered the hepatic components of the MS. Several scientific advances in understanding the association between NAFLD and MS have identified insulin resistance(IR) as the key aspect in the pathophysiology of both diseases. In the multi parallel hits theory of NAFLD pathogenesis, IR was described to be central in the predisposition of hepatocytes to be susceptible to other multiple pathogenetic factors. The recent knowledge gained from these advances can be applied clinically in the prevention and management of NAFLD and its associated metabolic changes. The present review analyses the current literature and highlights the new evidence on the metabolic aspects in the adult patients with NAFLD. | Ludovico Abenavoli Natasa Milic Laura Di Renzo Tomislav Preveden Milica Medi?-Stojanoska Antonino De Lorenzo | 2016 | World Journal of Gastroenterology2016，22，31： | 17 |
| 2 | Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease显示文摘AIM To determine the clinical effectiveness of nutritional counseling on reduction of non-alcoholic fatty liver disease(NAFLD) severity, weight loss, metabolic and anthropometric indexes and liver enzymes.METHODS Forty-six adults with NAFLD received a 6-mo clinical and a dietary intervention(based on Mediterranean diet) carried out respectively by a gastroenterologist and a nutritionist with counseling license. The counseling process consisted of monthly meeting(about 45 min each). The effect of the treatment was evaluated monitoring liver enzymes, metabolic parameters, cardiovascular risk indexes, NAFLD severity [assessed by ultrasound(US)] and related indexes. All parameters were assessed at baseline. Biochemistry was also assessed at mid-and end-interventions and US was repeated at end-intervention.RESULTS The percentage of patients with steatosis grade equal or higher than 2 was reduced from 93% to 48% and steatosis regressed in 9 patients(20%). At the end of the treatment the end-point concerning the weight(i.e., a 7% weight reduction or achievement/maintenance of normal weight) was accomplished by 25 out of 46 patients(i.e., 54.3%). As far as the liver enzymes is concerned, all three liver enzymes significantly decrease during the treatment the normalization was particularly evident for the ALT enzyme(altered values reduced from 67% down to 11%). Several parameters, i.e., BMI, waist circumference, waist-to-hip ratio, AST, ALT, GGT, HDL, serum glucose, Tot-Chol/HDL, LDL/HDL, TG/HDL, AIP, HOMA, FLI, Kotronen index, VAI, NAFLD liver fat score and LAP, showed a significant improvement(P < 0.01) between baseline and end-treatment.CONCLUSION Outcomes of this study further strengthen the hypothesis that Med Diet and more active lifestyle can be considered a safe therapeutic approach for reducing risk and severity of NAFLD and related disease states. The proposed approach may be proposed as a valid and recommended approach for improving the clinical profile of NAFLD patients. | Chiara Gelli Mirko Tarocchi Ludovico Abenavoli Laura Di Renzo Andrea Galli Antonino De Lorenzo | 2017 | World Journal of Gastroenterology2017，23，17： | 8 |
| 3 | Insulin resistance and liver steatosis in chronic hepatitis C infection genotype 3显示文摘Hepatitis C virus(HCV) infection is a common chronic liver disease worldwide.Non-alcoholic fatty liver disease and insulin resistance(IR) are the major determinants of fibrosis progression and response to antiviral therapy.The pathogenetic link between IR and chronic HCV infection is complex,and is associated with HCV genotype.Liver steatosis is the most common in the patients infected with genotype 3 virus,possibly due to direct effects of genotype 3 viral proteins.To the contrary,hepatic steatosis in the patients infected with other genotypes is thought to be mostly due to the changes in host metabolism,involving IR.In HCV genotype 3,liver steatosis correlates with viral load,reverts after reaching the sustained virologic response and reoccurs in the relapsers.A therapeutic strategy to improve IR and liver steatosis and subsequently the response to antiviral treatment in these patients is warranted. | Ludovico Abenavoli Mario Masarone Valentina Peta Natasa Milic Nazarii Kobyliak Samir Rouabhia Marcello Persico | 2014 | World Journal of Gastroenterology2014，20，41： | 7 |
| 4 | Alimentary regimen in non-alcoholic fatty liver disease:Mediterranean diet显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide.The mechanisms of the underlying disease development and progression are awaiting clarification.Insulin resistance and obesity-related inflammation status,among other possible genetic,dietary,and lifestyle factors,are thought to play the key role.There is no consensus concerning the pharmacological treatment.However,the dietary nutritional management to achieve weight loss is an essential component of any treatment strategy.On the basis of its components,the literature reports on the effectiveness of the Mediterranean diet in reducing cardiovascular risk and in preventing major chronic diseases,including obesity and diabetes.New evidence supports the idea that the Mediterranean diet,associated with physical activity and cognitive behaviour therapy,may have an important role in the prevention and the treatment of NAFLD. | Ludovico Abenavoli Natasa Milic Valentina Peta Francesco Alfieri Antonino De Lorenzo Stefano Bellentani | 2014 | World Journal of Gastroenterology2014，20，45： | 7 |
| 5 | Role of endoscopy in management of gastrointestinal complications of portal hypertension显示文摘The management of patients with gastrointestinal complications of portal hypertension is often complex and challenging. The endoscopy plays an important role in the management of these patients. The role of endoscopy is both diagnostic and interventional and in the last years the techniques have undergone a rapid expansion with the advent of different and novel endoscopic modalities, with consequent improvement of investigation and treatment of these patients. The choice of best therapeutic strategy depends on many factors: baseline disease, patient's clinical performance and the timing when it is done if in emergency or a prophylactic approaches. In this review we evaluate the endoscopic management of patients with the gastrointestinal complications of portal hypertension. | Carmelo Luigiano Giuseppe Iabichino Antongiulio Judica Clara Virgilio Valentina Peta Ludovico Abenavoli | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，1： | 5 |
| 6 | Non Alcoholic Fatty Liver: Epidemiology and Natural History显示文摘 | Mario Masarone Alessandro Federico Ludovico Abenavoli Carmela Loguercio Marcello Persico | 2014 | Reviews on Recent Clinical Trials2014，，3： | 4 |
| 7 | Adiponectin serum level in chronic hepatitis C infection and therapeutic profile显示文摘Hepatic steatosis is commonly seen in the patients with chronic hepatitis C virus(HCV) infection. HCV is closely associated with lipid metabolism,and viral steatosis is more common in genotype 3 infection owing to a direct cytopathic effect of HCV core protein. In non-genotype3 infection,hepatic steatosis is considered largely to be the result of the alterations in host metabolism; metabolic steatosis is primarily linked with HCV genotype 1. A d i p o s e t i s s u e s e c r e t e s d i f f e r e n t h o r m o n e s involved in glucose and lipid metabolisms. It has been demonstrated that adipocytokines are involved in the pathogenesis of non-alcoholic fatty liver disease,as the decreased plasma adiponectin levels,a soluble matrix protein expressed by adipoctyes and hepatocyte,are associated with liver steatosis. Various studies have shown that steatosis is strongly correlated negatively with adiponectin in the patients with HCV infection. The role of adiponectin in hepatitis C virus induced steatosis is still not completely understood,but the relationship between adiponectin low levels and liver steatosis is probably due to the ability of adiponectin to protect hepatocytes from triglyceride accumulation by increasing β-oxidation of free fatty acid and thus decreasing de novo free fatty acid production. | Valentina Peta Carlo Torti Natasa Milic Alfredo Foca Ludovico Abenavoli | 2015 | World Journal of Hepatology2015，7，1： | 4 |
| 8 | Genetic variation in eggplant for Nitrogen Use Efficiency under contrasting NO3^- supply显示文摘Eggplant(Solanum melongena L.) yield is highly sensitive to N fertilization, the excessive use of which is responsible for environmental and human health damage.Lowering N input together with the selection of improved Nitrogen-Use-Efficiency(NUE) genotypes, more able to uptake, utilize, and remobilize N available in soils, can be challenging to maintain high crop yields in a sustainable agriculture. The aim of this study was to explore the natural variation among eggplant accessions from different origins, in response to Low(LN) and High(HN)Nitrate(NO3^-) supply, to identify NUE-contrasting genotypes and their NUE-related traits, in hydroponic and greenhouse pot experiments. Two eggplants, AM222 and AM22, were identified as N-use efficient and inefficient,respectively, in hydroponic, and these results were confirmed in a pot experiment, when crop yield was also evaluated. Overall, our results indicated the key role of Nutilization component(NUt E) to confer high NUE. The remobilization of N from leaves to fruits may be a strategy to enhance NUt E, suggesting glutamate synthase as a key enzyme. Further, omics technologies will be used for focusing on C-N metabolism interacting networks. The availability of RILs from two other selected NUE-contrasting genotypes will allow us to detect major genes/quantitative trait loci related to NUE. | Antonio Mauceri Laura Bassolino Antonio Lupini Franz Badeck Fulvia Rizza Massimo Schiavi Laura Toppino Maria Rosa Abenavoli Giuseppe L.Rotino Francesco Sunseri | 2020 | Journal of Integrative Plant Biology2020，62，4： | 3 |
| 9 | Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis显示文摘 | Corpechot C Abenavoli L Rabahi N | | Hepatology0，，： | 3 |
| 10 | Silymarin: An option to treat non-alcoholic fatty liver disease显示文摘We have read with a great interest the review published by Singh et al, on the treatment options in alcoholic and non-alcoholic fatty liver disease, including various new targeted therapies that are currently under investigation. Recently, we described the health effects of the Mediterranean diet associated to an antioxidant complex rich in silymarin, to improve in overweight patients anthropometric parameters, glucose and lipid metabolism and intra-hepatic fat accumulation. | Carmela Colica Luigi Boccuto Ludovico Abenavoli | 2017 | World Journal of Gastroenterology2017，23，47： | 2 |
| 11 | Gamma hydroxybutyrric acid(GliB)withdrawal does not occur at therapeutic dosage显示文摘 | Addolorato G Leggio L Abenavoli L | 2005 | Drug Mcohol Depend2005，77，2： | 1 |
| 12 | A comparison of nitrogen use efficiency definitions in Citrus rootstocks 显示文摘 | Sorgona A Abenavoli M R Gringeri P G | 2006 | Scientia Horticulturae2006，109，： | 1 |
| 13 | Type 2 diabetes mellitus in chronic hepatitis C virus infection: risk factor or consequence? 显示文摘 | Abenavoli L Rouabhia S | 2013 | Expert Rev Gastroenterol Hepatol2013，7，4： | 1 |
| 14 | Root architecture plasticity of citrus rootstocks in response to nitrate availability显示文摘 | Sorgona A Abenavoli M R Gringeri P G Lupini A Cacco G | 2007 | J Plant Nutr2007，30，： | 1 |
| 15 | Marked decrease of serum Ca 125 levels after Denver shunt placement in a patient with cirrhosis and refractory ascites显示文摘 | Leggio L Abenavoli L D'Angelo C | 2006 | Dig Dis Sci2006，51，9： | 1 |
| 16 | Growth of Tomato and Zucchini Seedlings in Orange Waste Compost Media:pH and Implication of Dosage显示文摘 | Sorgona A Abenavoli M R Cacco G | | 0，，03： | 1 |
| 17 | Mefformin in the treat- ment of non-alcoholic fatty liver disease : safety, efficacy and mechanism显示文摘 | Rouabhia S Milic N Abenavoli L | 2014 | Expert Rev Gastroenterol Hepatol2014，8，4： | 1 |
| 18 | Madelung's disease: which surgical treatment 显示文摘 | Abenavoli F M Corelli R D'Erme | 2002 | Br J Plast Surg2002，55，6： | 1 |
| 19 | About alloderm 显示文摘 | ABENAVOLI F M CORELLI R | 2001 | Plast Reconstr Surg2001，108，7： | 1 |
| 20 | Biochemiealresponse to ursodeoxyeholic acid and long-term prognosis in primary bil- iary cirrhosis显示文摘 | Corpechot C Abenavoli L Rabahi N | 2008 | Hepatology2008，48，： | 1 |
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