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| 1 | Tacrolimus and mycophenolate mofetil as second-line treatment in autoimmune hepatitis:Is the evidence of sufficient quality to develop recommendations?显示文摘BACKGROUND The standard management of autoimmune hepatitis(AIH)is based on corticosteroids,alone or in combination with azathioprine.Second-line treatments are needed for patients who have refractory disease.However,high-quality data on the alternative management of AIH are scarce.AIM To evaluate the efficacy and safety of tacrolimus and mycophenolate mofetil(MMF)and the quality of evidence by using the Grading of Recommendations Assessment,Development and Evaluation approach(GRADE).METHODS A systematic review and meta-analysis of the available data were performed.We calculated pooled event rates for three outcome measures:Biochemical remission,adverse events,and mortality,with their corresponding 95%confidence intervals(CI).RESULTS The pooled biochemical remission rate was 68.9%(95%CI:60.4-76.2)for tacrolimus,and 59.6%(95%CI:54.8-64.2)for MMF,and rates of adverse events were 25.5%(95%CI:12.4-45.3)for tacrolimus and 24.1%(95%CI:15.4-35.7)for MMF.The pooled mortality rate was estimated at 11.5%(95%CI:7.1-18.1)for tacrolimus and 9.01%(95%CI:6.2-12.8)for MMF.Pooled biochemical remission rates for tacrolimus and MMF in patients with intolerance to standard therapy were 56.6%(CI:43.4-56.6)vs 73.5%(CI:58.1-84.7),and among non-responders were 59.1%(CI:48.7-68.8)vs 40.8%(CI:32.3-50.0),respectively.Moreover,the overall quality assessments using GRADE proved to be very low for all our outcomes in both treatment groups.CONCLUSION Tacrolimus and MMF are in practice considered effective for patients with AIH who are non-responders or intolerant to first-line treatment,but we found no high-quality evidence to support this statement. | Mohammadreza Abdollahi Neda Khalilian Ekrami Morteza Ghojazadeh H Marike Boezen Mohammadhossein Somi Behrooz Z Alizadeh | 2020 | World Journal of Gastroenterology2020，26，38： | 5 |
| 2 | Creati - Nine, blood urea nitrogen and thyroid hormone levels before and after haemodialysis显示文摘 | Shamsidini S Darvish - Moghaddam S Abdollahi H | 2006 | East Mediterr Heahh J2006，12，12： | 1 |
| 3 | Inhibition of alpha (v) beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy 显示文摘 | ABDOLLAHI A GRIGGS DW ZIEHER H | 2005 | Clin Cancer Res2005，11，17： | 1 |
| 4 | Rhabdomyolysis among acute human poisoning cases 显示文摘 | Talaie H Pajouhmand A Abdollahi M | 2007 | Hum Exp Toxicol2007，26，7： | 1 |
| 5 | The role of hypoxia in stem cell differentiation and therapeutics 显示文摘 | Abdollahi H Harris L J Zhang P | 2009 | J Surg Res2009，20，： | 1 |
| 6 | Mesophilic and thermophilic bioIeaching of copper from a chalcopyrite-containing molybdenite concentrate显示文摘 | Abdollahi H Shafaei S Z Noaparast M | 2014 | Int J Miner Process2014，128，1： | 1 |
| 7 | Net analyte signal-based simultaneous determination of ethanol and water by quartz crystal nanobalance sensor 显示文摘 | Mirmohseni A Abdollahi H Rostamizadeh K | 2007 | Analytica Chimica Acta2007，585，1： | 1 |
| 8 | Application of the H-point standard addition method to the speciation of Fe (lI) and Fe (III) with chromogenic mixed reagents显示文摘 | Safari A Abdollahi H | 2001 | Talanta2001，54，2： | 1 |
| 9 | Simultaneous spectrophotometric determina- tion of Chromium (Ⅵ) and Iron ( Ⅲ ) with ehromogenie mixed reagents by H -point standard addition method and partial squares regression 显示文摘 | Abdollahi H | 2001 | Analytical Chimica acta2001，442，： | 1 |
| 10 | Non-commuting graph of a group显示文摘 | ABDOLLAHI A AKBARI S MAIMANI H R | 2006 | J Algebra2006，298，： | 1 |
| 11 | Non-commuting graph of a group显示文摘 | ABDOLLAHI A AKBARI S MAIMANI H R | 2006 | J Algebra2006，298，： | 1 |
| 12 | Simuhaneous spectrophotometric determination of paracetamol buprofen and caffeine in pharmaceuticals by chemometric methods 显示文摘 | Khoshayand M R Abdollahi H Shariatpanahi M | 2008 | Science Direct2008，70，： | 1 |
| 13 | IL-10, TNF-alpha and IFN-gamma levels in serum and stomach mucosa of Helicobacter pylori-infected patients显示文摘 | Abdollahi H Shams S Zahedi M J | 2011 | Iran J Allergy Asthma Immunol2011，10，4： | 1 |
| 14 | A stable neural network- based observer with application to flexible-jolnt manipulators 显示文摘 | Abdollahi F Talebi H A Patel R V | 2006 | IEEE Transactions on Neural Networks2006，17，1： | 1 |
| 15 | Kinetics of Au ( HI ) extraction by DBC from hydro-chloric solution using Lewis cell显示文摘 | JAVANSHIR S ABDOLLAHY M ABOLGHASEMI H | 2011 | Int J Miner Process2011，98，1： | 1 |
| 16 | Angiotensin Ⅱ type Ⅰ receptor gene polymorphism:anthropometric and metabolic syndrome traits显示文摘 | M R Abdollahi T R Gaunt H E Syddall | 2005 | J Med Genet2005，42，： | 1 |
| 17 | The role of hypoxia in stem cell differentiation and therapeutics 显示文摘 | Abdollahi H Harris LJ Zhang P | 2011 | J Surg Res2011，165，1： | 1 |
| 18 | Simultaneous spectrophotometric determination of parae- etamol,ibuprofen and caffeine in pharmaceuticals by che- mometric methods 显示文摘 | Khoshayand M R Abdollahi H Shariatpanahi M | 2008 | Spectrochimica Acta Part A: Mo- lecular and Biomolecular Spectroscopy2008，70，3： | 1 |
| 19 | A Stable Neu- ral Network-based Observer with Application to Flexible-joint Manipulators显示文摘 | Abdollahi F Talebi H A Patel R V | 2006 | IEEE Transactions on Neural Networks2006，17，1： | 1 |
| 20 | A stable neural network-based observer with application to flexible-joint manipulators显示文摘 | Abdollahi F Talebi H A PatelR V | 2006 | IEEE Trans on Neural Networks2006，17，1： | 1 |
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