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| 1 | Yes相关蛋白通过肿瘤坏死因子受体相关因子6控制内皮活化和血管炎症显示文摘继发于异常的内皮激活的微血管炎症和内皮功能障碍在败血症和器官衰竭的病理生理学中起关键作用。抑制内皮细胞过度活化的内在信号传导机制尚未完全明了。该研究旨在确定Yes相关蛋白(Yes-associated protein,YAP)(Hippo通路的主要转录共激活剂)在调节内皮活化和血管炎症的强度和程度中的中心作用。 | 刘青 叶鹏 Lv Y Kim K Sheng Y Cho J Qain Z Zhao YY Hu G Pan D Malik AB | 2018 | 中华高血压杂志2018，26，8： | 20 |
| 2 | 二甲双胍长期治疗2型糖尿病患者以及维生素B12缺乏的危险性:随机安慰剂对照研究(摘要)显示文摘目的 研究接受胰岛素治疗的2型糖尿病患者中,二甲双胍所致维生素B12缺乏(〈150pmol/L)、低浓度维生素B12(150—220pmol/L)的发生率,以及叶酸和同型半胱氨酸的浓度。 | Jolien de Jager Adriaan Kooy Philippe Lehert Michiel G Wulffele Jan van der Kolk Daniel Bets Joop Verburg Ab J M Donker Coen D A Stehouwer 许翎岭(译) | 2010 | 英国医学杂志中文版2010，13，5： | 2 |
| 3 | Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin. | Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen | 2011 | World Journal of Gastroenterology2011，17，26： | 2 |
| 4 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 5 | Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community based study显示文摘 | Nieto F J Young TB Lind BK Shahar E Samet JM Redline S D’ Agostino RB Newman AB Lebowitz MD Picketing TG | 2000 | JAMA2000，283，： | 1 |
| 6 | In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML显示文摘 | White D Saunders V Lyons AB | 2005 | Blood2005，106，7： | 1 |
| 7 | Analysis of the clinical factors determining natural and maximal gait speeds in adults with a stroke patients显示文摘 | Nadeau S Arsenult AB Gravel D | 1999 | Am J Phys Med Rehabil1999，78，2： | 1 |
| 8 | Severe thrombocyto-penia predicts outcome in neonates with necrotizing enterocolitis显示文摘 | Kenton AB 0'Donovan D Cass DL | 2005 | J Perinatol2005，25，1： | 1 |
| 9 | Cystatin C levels me de- creased in acute myocardial in farction effect of eystatin C G73A gene polymorphism on plasma levels显示文摘 | Noto D Cefalu AB Barbagallo CM | 2005 | Int J Cardiul2005，101，2： | 1 |
| 10 | Expression of free fatty acid receptor GPR40 in the central nervous system of adult monkeys显示文摘 | Ma D Tao B Warashina S Kotani S Lu L Kaplamadzhiev DB Mori Y Tonchev AB Yamashima T | | 0，，04： | 1 |
| 11 | Cystatin C levels are decreased in acute myocardial infarction:effect of cystatin C G73A gone polymorphism on plasm levels显示文摘 | Noto D Cefalu AB Barbagllo CM | | 0，，2： | 1 |
| 12 | Photoluminescent carbogenic dots显示文摘 | Bourlinos AB Stassinopoulos A Anglos D | 2008 | Chem Mater2008，20，14： | 1 |
| 13 | Diagnostic value of CYFRA21-1 ,CEA,CA19-9,CA 15-3 and CA 125 assays in pleural effusions:analysis of 116 cases and review of the literature显示文摘 | Shitrit D Zingerman B Shitrit AB | 2005 | Oncologist2005，10，7： | 1 |
| 14 | American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage IT colon cancer 显示文摘 | Benson AB 3rd Schrag D Somerfield MR | 2004 | J Clin Oncol2004，22，16： | 1 |
| 15 | Surface functionalized carbogenic quantum dots显示文摘 | Bourlinos AB Stassinopoulos A Anglos D | 2008 | Small2008，4，4： | 1 |
| 16 | Immune complex - dependent remodeling of the airway vasculature in response to a chronic bacterial infection 显示文摘 | Aurora AB Baluk P Zhang D | 2005 | J Immunol2005，175，10： | 1 |
| 17 | Cystatin C levels are decreased in acute myocardial infarction,effect of cystatin C G73A gene polymorphism on plasma levels显示文摘 | Noto D Cefalu' AB Barbagallo CM | 2005 | Int J Cardiol2005，101，2： | 1 |
| 18 | Trends in the epidemiology of the first attack of acute panereatitis: a systematic review 显示文摘 | Yadav D Lowenfels AB | 2006 | Pancreas2006，33，4： | 1 |
| 19 | Shiga toxin activates complement and binds factor H:evidence for an active role of complement in hemolytic uremic syndrome 显示文摘 | Orth D Khan AB Naim A | 2009 | J Immunol2009，182，： | 1 |
| 20 | Preoperative neurological status in predicting surgical outcome of spinal epidural hematomas显示文摘 | Foo D Rossier AB | 1981 | Surg Neurol1981，15，： | 1 |
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