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| 1 | Micromanaging cardiac regeneration:Targeted delivery of micro RNAs for cardiac repair and regeneration显示文摘The loss of cardiomyocytes during injury and disease can result in heart failure and sudden death, while the adult heart has a limited capacity for endogenous regeneration and repair. Current stem cell-based regenerative medicine approaches modestly improve cardiomyocyte survival, but offer neglectable cardiomyogenesis. This has prompted the need for methodological developments that crease de novo cardiomyocytes. Current insights in cardiac development on the processes and regulatory mechanisms in embryonic cardiomyocyte differentiation provide a basis to therapeutically induce these pathways to generate new cardiomyocytes. Here, we discuss the current knowledge on embryonic cardiomyocyte differentiation and the implementation of this knowledge in state-ofthe-art protocols to the direct reprogramming of cardiac fibroblasts into de novo cardiomyocytes in vitro and in vivo with an emphasis on micro RNA-mediated reprogramming. Additionally, we discuss current advances on state-of-theart targeted drug delivery systems that can be employed to deliver these micro RNAs to the damaged cardiac tissue. Together, the advances in our understanding of cardiac development, recent advances in micro RNAbased therapeutics, and innovative drug delivery systems, highlight exciting opportunities for effective therapies for myocardial infarction and heart failure. | Jan AAM Kamps Guido Krenning | 2016 | World Journal of Cardiology2016，8，2： | 6 |
| 2 | Effects of soy isoflavones on estrogen and phytoestrogen metabllism in premenopausal women 显示文摘 | Xu X Duncan AAM Merz BE | 1998 | Cancer Epidem iol Biomark Prey1998，7，12： | 1 |
| 3 | Evidenced-based investigations and treatments of recurrent pregnancy loss显示文摘 | Christiansen OB Nybo AAM Bosch E | 2005 | Fertil Steril2005，83，4： | 1 |
| 4 | Liquid chromatography with triple-quadrupole or quadrupole-time of flight mass spectrometry for screening and confirmation of residues of pharmaceuticals in water 显示文摘 | Stolker AAM Niesing W Hogendoorn EA | 2007 | Anal Bioanal Chem2007，378，： | 1 |
| 5 | Cardiac sodiumchan- nel overlap syndromes: different faces of SCNSA mutations 显示文摘 | Remme CA Wilde AAM Bezzina CR | 2008 | Trends Cardiovase Med2008，18，3： | 1 |
| 6 | Expressive Writing therapy for victims of trauma显示文摘 | Thabet AAM | 2006 | Arabosvnet J2006，12，： | 1 |
| 7 | Comparison of different methods for state estimation 显示文摘 | Holten L Gjelsvik A Aam S | 1988 | IEEE Transactions on Power Systems1988，3，4： | 1 |
| 8 | 油菜秸秆厌氧发酵产气特性与工艺参数优化显示文摘为了探索油菜秸秆厌氧发酵产沼气的潜力,本文采用正交试验设计的方法,研究了温度、总固体浓度、接种率和C/N对油菜秸秆厌氧发酵过程中产气量随时间的变化规律和产气特性。结果表明,油菜秸秆厌氧发酵最高日产气量达到4.25 L/d(厌氧消化器容积为2.5 L),发酵周期中的最高累积产气量达到70.665 L,产气潜力达到0.36973 L/g。通过对实验结果的方差和极差分析,得到厌氧发酵的最佳工艺参数为发酵温度40℃,总固体浓度10%,接种率20%,C/N=25:1。各因素对产气量的影响主次依次为:温度(A)>总固体浓度(B)>接种率(C)>C/N(D)。温度对产气量的影响显著,总固体浓度和接种率对产气量的影响不显著。通过对试验结果的分析,得出油菜秸秆在最优条件下的总产气量和TS产气量分别将达到72.6619 L和0.39576 L/g。 | 孙全平 邱凌 Hassanein AAM 周彦峰 | 2014 | 西藏农业科技2014，36，3： | 1 |
| 9 | Consensus report,proposed diagnostic criteria for the brugada syndrome显示文摘 | Wilde AAM Antzelebitch C Borggrefe M | 2002 | European Heart Journal2002，23，： | 1 |
| 10 | Hactel's augment malrix method - a rapid method improving numerical stability in power system static estimation 显示文摘 | Gjelsvik A Aam S Holten L | 1985 | IEEE Transactions on Power Apparatus and Systems1985，104，11： | 1 |
| 11 | Ionic liquid supported acid/base-catalyzed production of biodiesel显示文摘 | Lapis AAM de Oliveira LF Neto BAD | 2008 | Chemsuschem2008，1，89： | 1 |
| 12 | Proposed diagnostic criteria for the Brugada syndrome:a consensus report显示文摘 | Wilde AAM Antzelevitch C Borggrefe M | 2002 | Circulation2002，106，19： | 1 |
| 13 | Cesarean section and increased body mass index in school children:two cohort studies from distinct socioeconomic background areas in Brazil显示文摘 | Goldani MZ Barbieri MA da Silva AAM | 2013 | Nutr J2013，，12： | 1 |
| 14 | Strategies for the isolation of cellulolytic fungi for composting of wheat straw 显示文摘 | Hart T D F AAM De Leij Kinsey G | 2002 | World Journal of Microbiology & Biotechnology2002，18，： | 1 |
| 15 | Control of eukaryotie protein synthesis by upstream open reading frames in the 5'-untranslated region of an Mrna 显示文摘 | Meijer HA Thomas AAM | 2002 | Biochem J2002，367，： | 1 |
| 16 | Spectrophotometric determination of omeprazole,lansoprazole and pantoprazole in pharmaceutical formulations显示文摘 | WAHBI AAM ABDEL-RAZAK O GAZY AA | 2002 | J Pharm Biomed Anal2002，30，4： | 1 |
| 17 | Percutaneous transluminal angioplasty in the treatment of stenosis of arteriovenous fistulae for hemodialysis显示文摘 | Miquelin DG Reis LF Da Silva AAM | 2008 | Internat Arch Med2008，1，： | 1 |
| 18 | 显示文摘 | Rahman I Schadewijk AAM Hiemstra PS | 2000 | Free Radic Biol Med2000，28，6： | 1 |
| 19 | Secondary intention healing after excision of nonmelanoma skin cancer of the head and neck: statistical evaluation of prognostic values of wound characteristics and final cosmetic results 显示文摘 | Van Der Eerden PA Lohuis PJEM Hart AAM | 2008 | Plast Reconstr Surg2008，122，6： | 1 |
| 20 | Herpes simplex vi- rus-associated acute liver failure, a difficult diagnosis with a poor prognosis 显示文摘 | ICHAI P ROQUE AAM SEBAGH M | 2005 | Liver Transpl2005，11，12： | 1 |
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