|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Soil Microbiological Activity and Carbon Dynamics in the Current Climate Change Scenarios:A Review显示文摘Microbial activities are affected by a myriad of factors with end points involved in nutrient cycling and carbon sequestration issues.Because of their prominent role in the global carbon balance and their possible role in carbon sequestration, soil microbes are very important organisms in relation to global climate changes. This review focuses mainly on the responses of soil microbes to climate changes and subsequent effects on soil carbon dynamics. An overview table regarding extracellular enzyme activities(EAA) with all relevant literature data summarizes the effects of different ecosystems under various experimental treatments on EAA. Increasing temperature, altered soil moisture regimes, and elevated carbon dioxide significantly affect directly or indirectly soil microbial activities.High temperature regimes can increase the microbial activities which can provide positive feedback to climate change, whereas lower moisture condition in pedosystem can negate the increase, although the interactive effects still remain unanswered. Shifts in soil microbial community in response to climate change have been determined by gene probing, phospholipid fatty acid analysis(PLFA),terminal restriction length polymorphism(TRFLP), and denaturing gradient gel electrophoresis(DGGE), but in a recent investigations,omic technological interventions have enabled determination of the shift in soil microbe community at a taxa level, which can provide very important inputs for modeling C sequestration process. The intricacy and diversity of the soil microbial population and how it responds to climate change are big challenges, but new molecular and stable isotope probing tools are being developed for linking fluctuations in microbial diversity to ecosystem function. | Javid A.SOFI Aabid H.LONE Mumtaz A.GANIE Naseer A.DAR Sajad A.BHAT Malik MUKHTAR Mohd Ashraf DAR Shazia RAMZAN | 2016 | Pedosphere2016，26，5： | 13 |
| 2 | Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy显示文摘Colorectal cancer(CRC)is a predominant life-threatening cancer,with liver and peritoneal metastases as the primary causes of death.Intestinal inflammation,a known CRC risk factor,nurtures a local inflammatory environment enriched with tumor cells,endothelial cells,immune cells,cancer-associated fibroblasts,immunosuppressive cells,and secretory growth factors.The complex interactions of aberrantly expressed cytokines,chemokines,growth factors,and matrix-remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease outcomes.Mounting evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment,which is partly achieved by the recruitment of immunosuppressive cells.These cells impart features such as cancer stem cell-like properties,drug resistance,invasion,and formation of the premetastatic niche in distant organs,promoting metastasis and aggressive CRC growth.A deeper understanding of the cytokineand chemokine-mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for CRC.Here,we summarized the current knowledge of cytokine-and chemokine-mediated crosstalk in the inflammatory tumor microenvironment,which drives immunosuppression,resistance to therapeutics,and metastasis during CRC progression.We also outlined the potential of this crosstalk as a novel therapeutic target for CRC.The major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review. | Ajaz A.Bhat Sabah Nisar Mayank Singh Bazella Ashraf Tariq Masoodi Chandra P.Prasad Atul Sharma Selma Maacha Thasni Karedath Sheema Hashem Syed Besina Yasin Puneet Bagga Ravinder Reddy Michael P.Frennaux Shahab Uddin Punita Dhawan Mohammad Haris Muzafar A.Macha | 2022 | Cancer Communications2022，42，8： | 8 |
| 3 | Diversity and regeneration status of Sarkot Van Panchyat in Garhwal Himalaya, India显示文摘We investigated the floristic composition, phytosociological and regeneration status of Sarkot Van Panchyat (community forest) in Chamoli district of Garhwal Himalaya. A total of 52 plant species of 46 genera and 26 families were recorded, which included 12 trees, 18 shrubs and 22 herb species. Quercus leucotrichophora was dominant tree species in sapling and seedling layers, followed by Lyonia ovalifolia and Rhododendron arboreum.Out of 12 tree species, 7 species in seedling stage and 8 species in sapling stage were recorded in the study area. The 44.41% species in the study area showed good regeneration status, 16.66% species were fairly regenerating,and 8.33% species showed poor regeneration status, while 33% species were not regenerating. Number of individuals from lower girth classes (0 10 cmand 10 30 cm) showed decreasing trend with the increase in size of girth class. Shannon index (H) for trees, shrubs and herbs was recorded as 1.82,2.24 and 2.41 respectively. Simpsons index (CD) was recorded as 0.21, 0.12and 0.12 for trees, shrubs and herbs respectively. The forest should be divided into compartments for better management purpose and each compartment should be closed for five years to assist regeneration and enrichment planting may also be carried out for sustainable management. | Nazir A.Pala A.K.Negi Yogesh Gokhale Jahangeer A.Bhat N.P.Todaria | 2012 | Journal of Forestry Research2012，23，3： | 4 |
| 4 | Wood specific gravity of some tree species in the Garhwal Himalayas, India显示文摘Estimation of terrestrial biomass depends critically on reliable information about wood specific gravity of forest trees. In recent years, wood specific gravity has become more important when exploring the universality of functional traits of plants and estimating their global carbon stocks. To estimate their specific gravity, wood samples were collected from a total of 34 tree species, 30 from lower elevations and 4 from upper elevations in the Garhwal Himalayas, India. The results show that the average wood specific gravity was 0.631 (ranging between 0.275 ± 0.01 and 0.845 ± 0.03) for the species at lower elevations and 0.727 (ranging between 0.628 ± 0.02 and 0.865 ± 0.02) for the upper elevations. The average wood specific gravity for the upper elevation species was 9.6% greater than that for the species at lower elevations. Aegle marmelos among the lower elevation species and Quercus leucotrichophora among the upper elevation species had the highest wood specific gravity, which were 0.845 ± 0.03 and 0.865 ± 0.02, respectively. | Mehraj A.SHEIKH Munesh KUMAR Jahangeer A.BHAT | 2011 | Forestry Studies in China2011，13，3： | 2 |
| 5 | Correction: Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy显示文摘Correction to:Signal Transduction and Targeted Therapy http://gffzzd3cc09b8251d45dfs6f0uuokbqk0v6fbb.ffgz.tsg.suse.edu.cn/10.1038/s41392-020-00419-w,published online 12 January 2021 After online publication of the article1,the authors noticed an error in affiliation of co-authors Dr.Nissar A.Wani.Dr.Wani is erroneously linked to Sidra Medicine,Doha,Qatar who is actually working at the Department of Biotechnology,School of Life Sciences,Central University of Kashmir,Ganderbal,Jammu&Kashmir,India.Also,the department name'Cancer Research Department'for the first author Ajaz A.Bhat is missing. | Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael El-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris Muzafar A.Macha | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 6 | Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy显示文摘Head and neck squamous cell carcinoma(HNSCC)is a very aggressive disease with a poor prognosis for advanced-stage tumors.Recent clinical,genomic,and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of HNSCC.Despite signifcant advances in multimodal therapeutic interventions,failure to cure and recurrence are common and account for most deaths.It is becoming increasingly apparent that tumor microenvironment(TME)plays a critical role in HNSCC tumorigenesis,promotes the evolution of aggressive tumors and resistance to therapy,and thereby adversely affects the prognosis.A complete understanding of the TME factors,together with the highly complex tumor-stromal interactions,can lead to new therapeutic interventions in HNSCC.Interestingly,different molecular and immune landscapes between HPV^(+ve) and HPV^(-ve)(human papillomavirus)HNSCC tumors offer new opportunities for developing individualized,targeted chemoimmunotherapy(CIT)regimen.This review highlights the current understanding of the complexity between HPV^(+ve) and HPV^(-ve) HNSCC TME and various tumor-stromal cross-talk modulating processes,including epithelial-mesenchymal transition(EMT),anoikis resistance,angiogenesis,immune surveillance,metastatic niche,therapeutic resistance,and development of an aggressive tumor phenotype.Furthermore,we summarize the recent developments and the rationale behind CIT strategies and their clinical applications in HPV^(+ve) and HPV^(-ve) HNSCC. | Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael EI-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris Muzafar A.Macha | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 7 | Plating the radial shaft on the lateral surface: An outcome study显示文摘Purpose:Plate fixation is the gold standard for the treatment of displaced forearm shaft fractures in adults. Conventionally radial shaft fractures will be plated either on the volar surface or on the dorsal surface depending on which approach has been chosen. The lateral surface of the radius provides an even and uniformly curved area for placing a plate. It has the advantage of restoring and easy assessing the radial bow after surgery. We designed a prospective study to observe the outcome of lateral plating of radius shaft fractures.Methods:Nineteen patients were included in this study performed in Government Medical College, Jammu, India. Among them, 13 had fractures of both the forearm bones and 6 had isolated radial shaft fracture. Three patients had Galeazzi fracture dislocation. Fixation was done within 36 h of injury in all using 3.5 mm limited contact dynamic compression plate or locking compression plate applied to the lateral surface of the radius. Ulna was fixed in routine manner.Results:Union was achieved in 18 out of 19 patients, after a mean time of 17.44 weeks. According to Anderson et al.'s criteria, 12 patients had excellent results, 5 had satisfactory and 1 had unsatisfactory result. There was one failure (nonunion).Conclusion:The outcomes including rate of union were comparable to those in the existing literature. Plating the radial shaft on the lateral surface is a viable alternative to volar or dorsal plating of the radius. Larger studies with randomized data are needed to assess whether it has any superiority over other existing techniques. | Muhammad Haseeb Khalid Muzafar Khurshid A.Bhat Abdul Ghani Omeshwar Singh | 2018 | Chinese Journal of Traumatology2018，21，6： | 1 |
| 8 | Ethnomedicinal knowledge of indigenous communities and pharmaceutical potential of rainforest ecosystems in Fiji Islands显示文摘The World Health Organization recently raised concerns about antimicrobial resistance and lack of novel antibiotics in the health sector. The success rate of drug discovery is higher when chemical constituents are sourced from natural products and when drug candidates are based on the indigenous knowledge of local communities. Tropical rainforests are an important source of medicinal plants for traditional healthcare systems. The pharmaceutical industry also recognizes the potential of rainforests in novel drug development. However, habitat degradation and loss of traditional knowledge are endangering the healing powers of nature. The islands of Fiji have a rich cultural history of traditional medicine and a number of medicinal plants are sourced from the country's rainforest ecosystems. While deforestation and forest degradation are decimating unique rainforest biodiversity and reducing access to medicinal plants in the wild, inter-generational erosion of ethnobotanical knowledge is attributed to acculturation, rural-urban migration and their effects on the transmission of oral traditions from one generation to another. Under these conditions, plants may disappear before their therapeutic value is formally identified. This review summarizes the importance of traditional medicinal knowledge and the potential for drug discovery from the tropical rainforest ecosystems of Fiji. However, there are several challenges that need to be addressed to realize the true potential of ethnopharmacology in this country. | Shipra Shah Jahangeer A.Bhat | 2019 | Journal of Integrative Medicine2019，17，4： | 0 |
| 9 | Restoration of GABA_(B) receptor expression in cerebral ischemia:a promising novel neuroprotective strategy显示文摘Although stroke is a major global health problem, a pharmacological treatment to inhibit ongoing neuronal death in patients is still lacking. In cerebral ischemia, the prevailing form of stroke, severely reduced blood supply by obstruction of blood vessels deprives neurons from oxygen and glucose, eventually leading to metabolic derailment and death of neurons in the affected brain area. | Musadiq A.Bhat Mohammad Hleihil Dietmar Benke | 2023 | Neural Regeneration Research2023，18，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员